The impact of COVID-19 non-pharmaceutical interventions on HIV care continuum in China: An interrupted time series analysis.

Poisson segmented regression analysis showed that the median time intervals increased by 59·3% (1·593,1·270-1·997; Table 2 and Figure 2 D), 58·0% (1·580,1·265-1·973) and 56·7% (1·567,1·259-1·950) during the first, second and third weeks of the NPIs period, respectively; the median time intervals showed a decreasing trend of 1·4% (0·986,0·980-0·992) per week in the post-NPIs period, and largely returned to the expected level (1·072,0·860-1·335) by the end of 2020.

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Poisson segmented regression analysis showed that the number of PEP prescriptions decreased by 71·5% in the first week of the NPIs period (20-26 January, 2020) (incidence rate ratio [IRR] 0·285; 95% confidence interval [CI] 0·192-0·423; Table 2 and Figure 2 A; compared with counterfactual), then 71·2% (0·288, 0·197-0·423) and 70·8% (0·292, 0·201-0·424) in the second (27 January-2 February, 2020) and third week (3-9 February, 2020), respectively; the number of prescriptions showed an increasing trend of 2·4% per week in the post-NPIs period (1·024,1·012-1·037), and by the end of 2020 (28-31 December, 2020) the number of prescriptions still had not reached expected level (0·523,0·394-0·696).

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