Low-Dose Tacrolimus Promotes the Migration and Invasion and Nitric Oxide Production in the Human-Derived First Trimester Extravillous Trophoblast Cells In Vitro.

Int J Mol Sci · 2022 · PMC9369346 · PMID 35955565

Europe PMC DOI

hedged sentence

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

a statistical trendp = 0.06so close (0.05 < p ≤ 0.1)

In our experience, despite a statistical trend ( p = 0.06) in inducing IL6 protein expression in HTR-8/SVneo cells, a low-dose tacrolimus of 10 ng/mL was not sufficient to significantly induce the expression of this pleotropic cytokine in these EVT cells when cultured under nitrosative stresses in vitro ( Supplementary Figure S2 ).

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