Postmitotic accumulation of histone variant H3.3 in new cortical neurons establishes neuronal chromatin, transcriptome, and identity.

Proc Natl Acad Sci U S A · 2022 · PMC9371731 · PMID 35930666

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highly significantno p-value reported

Our analysis revealed a significant overrepresentation of NPC-selective genes in up-regulated DEGs ( P hyper = 1.4E-11, 12% of up-regulated DEGs), including NPC markers Pax6 , Prom1 , and Vim , and a highly significant enrichment of neuron-selective genes in down-regulated DEGs ( P hyper = 2.8E-43, 16% of down-regulated DEGs), including neuronal markers Syn1 , Slc17a7 ( Vglut1 ), and Gap43 .

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