We next profiled gene expression changes that occurred after attenuating levels of H3Q5dop during heroin abstinence and identified highly significant overlap with regulation of opioid and dopaminergic signaling, cytokine pathways, and synaptic transmission/regulation of neuronal action potential related processes.
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Histone H3 dopaminylation in ventral tegmental area underlies heroin-induced transcriptional and behavioral plasticity in male rats.
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