Boosting the peripheral immune response in the skeletal muscles improved motor function in ALS transgenic mice.

52 Although an increasing trend in CD4 and CD8a transcript levels was recorded upon MCP1 boosting, FoxP3 mRNA was significantly upregulated at 14 weeks, suggesting an increased infiltration of T regulatory lymphocytes (Tregs) compared with the scAAV9(empty) group ( Figures 2 G–2I).

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