Crohn's disease in endoscopic remission, obesity, and cases of high genetic risk demonstrates overlapping shifts in the colonic mucosal-luminal interface microbiome.

Beta diversity analysis using Bray-Curtis dissimilarity did not identify statistically significant differences in bacterial composition by disease behavior adjusting for gender, age, and obesity, though there was a trend towards significance in the cecum ( p =0.07) (Fig. 5 B).

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Beta diversity analysis demonstrated a highly significant association of CD status with bacterial composition in both the sigmoid and cecum MLI adjusting for gender, age, and obesity status (Fig. 2 B).

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