Biochemical and clinical biomarkers in adult SMA 3-4 patients treated with nusinersen for 22 months.

Ann Clin Transl Neurol · 2022 · PMC9380134 · PMID 35833245

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just failed to reach significanceno p-value reported

Interestingly, the correlation between CHIT1 and YKL‐40 in untreated patients at baseline just failed to reach significance, despite the fact that both are expressed by glial cells that are known to play a role in neuroinflammation in SMA. 3 However, this could simply be due to the sample size of the study.

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a decreasing trendno p-value reported

YKL‐40 concentrations in CSF showed a decreasing trend during treatment with nusinersen but this was not significant ( p = 0.275; Fig. 1B ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.