Synthesis and anti-melanoma effect of 3-O-prenyl glycyrrhetinic acid against B16F10 cells <i>via</i> induction of endoplasmic reticulum stress-mediated autophagy through ERK/AKT signaling pathway.

Front Oncol · 2022 · PMC9380594 · PMID 35982963

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Transcriptional factor CHOP also plays a highly significant role in ER stress-mediated apoptosis, as the sustained activation of UPR causes upregulation of CHOP via GRP78/ATF4 signaling pathway ( 42 ).

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