Blood-based Aβ42 increases in the earliest pre-pathological stage before decreasing with progressive amyloid pathology in preclinical models and human subjects: opening new avenues for prevention.

Linear regression analysis demonstrated a highly significant linear relation (slope significantly different from 0 with p -value < 0.0001) between t-tau serum concentrations and p-tau concentrations and aggregated tau concentrations in total brain homogenates (Fig. 3 c, d).

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