The repeat length of <i>C9orf72</i> is associated with the survival of amyotrophic lateral sclerosis patients without <i>C9orf72</i> pathological expansions.

Front Neurol · 2022 · PMC9381700 · PMID 35989899

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0.0480

closest p · 1.0× alpha

0.0480

boldest claim

The sentences

marginally significantp = 0.048actually significant

Taking the known SoFT mutation status in 537 patients into comparison, the marginally significant difference in survival time was present in patients with TARDBP mutations [ TARDBP (+): 2 vs. >2: 58.1 vs. 16.3 months, p = 0.048], while there was no significant difference in patients carrying SOD1 (log-rank p = 0.22), FUS (log-rank p = 0.55), or SoFT(–) (log-rank p = 0.08).

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