Co-expression network analysis of human tau-transgenic mice reveals protein modules associated with tau-induced pathologies.

iScience · 2022 · PMC9382322 · PMID 35992067

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highly significantp-value = 1.0e-16actually significant

Protein-protein interaction (PPI) analysis using STRING ( Szklarczyk et al., 2019 ) revealed that the hub proteins, including MSN, EZR, C1qa, a key component of the complement cascade, and GFAP, belong to a PPI network with highly significant interactions (p-value = 1.0e-16) ( Figure 4 B).

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