Translation of the 27-gene immuno-oncology test (IO score) to predict outcomes in immune checkpoint inhibitor treated metastatic urothelial cancer patients.

J Transl Med · 2022 · PMC9382843 · PMID 35974414

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

narrowly missed significancep = 0.06so close (0.05 < p ≤ 0.1)

IC2/3 narrowly missed significance for OS in this cohort (HR = 0.53 p = 0.06).

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failed to reach significanceno p-value reported

Unfortunately, a Phase 3 confirmatory study, IMvigor211 ( NCT02302807 ), using the primary endpoint of OS where patients with IC2/3 status were tested first in a hierarchical sequence, failed to reach significance [ 9 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.