The expression of CCL5 in the skin revealed an increasing trend 2 weeks following AHCT while infiltrating cells were dominantly CCR5 positive. 45 The skin pathological examination of patients who developed acute GVHD showed that infiltrating CD4 + and CD8 + T cells highly expressed CCR5. 46 In a murine model, CCR5 + CD8 + T cells infiltrated the liver, while CCL3 concentration increased in intralobular biliary epithelial cells, endothelial cells, and macrophages, resulting in liver damage.
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