Impact of introducing procalcitonin testing on antibiotic usage in acute NHS hospitals during the first wave of COVID-19 in the UK: a controlled interrupted time series analysis of organization-level data.

The effect of the percentage of COVID-19-positive admissions per total admissions each week was also highly significant ( P < 0.001), DDDs per admission increasing by 0.32 (95% CI: 0.29–0.34) with each 1% increase in COVID-19-positive admissions, which ranged between 0% and 5% for most trusts in most weeks (Figure S4 ).

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