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covSampler: A subsampling method with balanced genetic diversity for large-scale SARS-CoV-2 genome data sets.

Virus Evol · 2022 · PMC9384632 · PMID 36533145

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a decreasing trendno p-value reported
For comprehensively subsampled genomes, most genome sites with a high mutation frequency in global genomes showed a decreasing trend in mutation frequency in the subsampled genomes ( Fig. 3D ).

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