Role of sodium salicylate in <i>Staphylococcus aureus</i> quorum sensing, virulence, biofilm formation and antimicrobial susceptibility.

In the liquid-based assay, treatment with NaSa (0.1, 1, 10 mM) produced no effect on spa after 4 h, but an increasing trend in expression at ≤ 1 mM was observed after 24 h ( Figure 4B ).

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The highest concentration of NaSa (10 mM) showed a decreasing trend in the secretion of Hla ( Figures 3A,B and Supplementary Material 3 ), ScpA ( Figures 3C,D and Supplementary Material 4 ) and Hld ( Figures 3E,F and Supplementary Material 5 ), whereas the secretion of Protein A ( Figures 3G,H and Supplementary Material 6 ) was not affected by NaSa.

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