Germline thymidylate synthase deficiency impacts nucleotide metabolism and causes dyskeratosis congenita.

Am J Hum Genet · 2022 · PMC9388389 · PMID 35931051

Europe PMC DOI

hedged sentence

0.0000

closest p · 0.0× alpha

0.0000

boldest claim

The sentences

highly significantp < 0.000001actually significant

This series of six LOF variants is a highly significant finding, given that there are only four LOF TYMS variants in the gnomAD database, which comprises more than 125,000 individuals (p < 0.000001: Chi squared with Yates’ correction).

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