Reply: The forced correlation between ISCHEMIA and the inaccurate CABG recommendations of the 2021 American College of Cardiology/American Heart Association/Society for cardiovascular Angiography coronary revascularization guidelines.

5 Thus, invasive strategy was associated with better event-free survival and a decreasing trend in cardiovascular mortality even in patients with less severe CAD than those referred routinely for CABG. 5 In addition, we had previously discussed why CABG and percutaneous coronary intervention are different treatment modalities with different indications and outcomes and should not be lumped together as equivalent revascularization procedures. 2 Finally, more of the patients in the invasive-strategy group of ISCHEMIA received medical therapy only than CABG.

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