A broad-spectrum beta-lactam-sparing stewardship program in a middle-income country public hospital: antibiotic use and expenditure outcomes and antimicrobial susceptibility profiles.

Between 2000 and 2010, the global consumption of carbapenems and polymyxins increased by 45% and 13%, respectively, 5 followed by an increasing trend until 2015. 11 However, antibiotic consumption is a determinant driver for AMR. 12 , 13 , 14 , 15 , 16 Strategies such as antimicrobial stewardship programs (ASP) appear to be an efficient way to improve clinical and microbial outcomes; such programs aim to reduce the inadequate use of antibiotics and the associated expenditure. 17 , 18 The aim of this study was to evaluate antibiotic use, the associated costs, and the bacterial susceptibility profiles after implementation of a broad-spectrum beta-lactam-sparing ASP.

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