Acute exacerbations of chronic rhinosinusitis: The current state of knowledge.

20 In specific patients reporting frequent AECRS (defined as three or more antibiotic courses in the last year), there was a highly significant 62% reduction in antibiotic use for AECRS with the use of biologics. 20 Although biologics are not currently approved for CRSsNP, they can be a useful, yet expensive, adjunct in CRSwNP patients and have been shown to reduce AECRS. 20 , 46 Recent trials specifically studying the efficacy

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