Functional Brain Connectivity Prior to the COVID-19 Outbreak Moderates the Effects of Coping and Perceived Stress on Mental Health Changes: A First Year of COVID-19 Pandemic Follow-up Study.

Finally, the second model (a- R 2 = 0.539) showed a trend toward significance between the limbic network SyS variable and the coping strategies’ effect on the association between perceived stress and PHQ-4 (β = −0.024, t = −1.727, p = .085) in the sense that a higher limbic network SyS could be related to an increased effect of coping strategies as a psychological regulatory mechanism ( Figure S4 ).

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