PAX5 fusion genes are frequent in poor risk childhood acute lymphoblastic leukaemia and can be targeted with BIBF1120.

A highly significant impact on EFS was confirmed for Ph-like (hazard ratio (HR)=2·93, p -value=0·003) as well as for assignment to final High-Risk group (HR=2·25, p -value=0·03), while age and WBC at diagnosis did not have a significant impact on outcome ( Table 2 ).

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