<i>Padi2/3</i> Deficiency Alters the Epigenomic Landscape and Causes Premature Differentiation of Mouse Trophoblast Stem Cells.

Notably, gene ontology analysis on genes associated with hypomethylated CGIs (within 2kb) produced the term “trophoblast giant cell differentiation” ( Figure 4 F), a highly significant hit as placenta-associated terms are often under-represented in such databases.

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