Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19.

Proc Natl Acad Sci U S A · 2022 · PMC9407655 · PMID 35943978

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highly significantno p-value reported

In a rapid and basic biological test of this dataset, we observed highly significant correlations of Shannon entropy with the frequencies of CD45RA + CCR7 + αβ T cells that largely denote unexpanded, naïve T cells that would be expected to be highly diverse ( Fig. 1 D ).

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