Complexing the Oncolytic Adenoviruses Ad∆∆ and Ad-3∆-A20T with Cationic Nanoparticles Enhances Viral Infection and Spread in Prostate and Pancreatic Cancer Models.

When the Ad-resistant pancreatic stellate cell line PS1 was infected with Ad5wtGFP ± AuNPs, a highly significant increase in uptake and EGFP-expression was observed after 24 and 48 h, from 0.2% to 26 ± 8% and from 1% to 50 ± 9%, (500 ppc), respectively.

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