Comprehensive analysis of endoplasmic reticulum-related and secretome gene expression profiles in the progression of non-alcoholic fatty liver disease.

Front Endocrinol (Lausanne) · 2022 · PMC9412753 · PMID 36034446

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an increasing trendno p-value reported

In our study, we identified the hub genes and demonstrate an increasing trend in the progression of NAFLD ( Figure 4 ). 8 out of top 20 hub genes have been reported to be associated to NAFLD by literature searching, including STING1 , COL1A1 , IGFBP7 , PTGDS , TIMP1 , COL1A2 and COL3A1 .

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an elevated trendno p-value reported

Livers of ob/m and ob/ob mice were harvested for RNA sequencing and we found that most of the identified hub genes exhibited an elevated trend ( Figures 5B, C ).

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