In some studies, the mechanism of metformin alone or in combination with bioactive substances and other drugs to improve symptoms of patients has been further clarified: In rat experiments, it was found that the SIRT1 and AMPK immune reactivity were significantly increased and showed an increasing trend after metformin alone or in combination with resveratrol and exenatide, and the ovarian morphology and related metabolic indicators were significantly improved in PCOS rats.
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The role of Sirtuin 1 in the pathophysiology of polycystic ovary syndrome.
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