Barely Significant
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Hotspots of single-strand DNA "breakome" are enriched at transcriptional start sites of genes.

Front Mol Biosci · 2022 · PMC9420937 · PMID 36046604

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highly significantp -value < 2.16E-16actually significant
This overlap was highly significant as represented by the odds ratio of 38.41-fold over what would be expected by random chance and the p -value < 2.16E-16 (two-sided binomial test).

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