Metabolic reprogramming and crosstalk of cancer-related fibroblasts and immune cells in the tumor microenvironment.

Front Endocrinol (Lausanne) · 2022 · PMC9421293 · PMID 36046791

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incredibly significantno p-value reported

However, there are still problems of low efficiency and high adverse effects, the reason for which is incredibly significant is the metabolic reprogramming-mediated immunosuppression of the microenvironment ( 186 , 187 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.