Clonal Hematopoiesis and Epigenetic Age Acceleration in Elderly Danish Twins.

Both these findings are contrary to Nachun et al, 7 who reported borderline significance for mortality for CHIP carriers versus non-carriers, respectively, a significant association for mortality for AgeAccelHG+ versus others (see Suppl.

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Finally, CHIP carriers of the present study population who were not double accelerated (ie, individuals being CHIP+/AgeAccelHG−, N = 54) or individuals without CHIP yet being double accelerated (ie, individuals being CHIP−/AgeAccelHG+, N = 30) revealed a significant or borderline significant association with increased mortality compared with individuals without CHIP mutations and without double acceleration (ie, individual being CHIP−/AgeAccelHG−, N = 101): HR = 1.34, 95% CI = 0.96–1.88, P = 0.086 for CHIP+/AgeAccelHG−, and HR = 1.58, 95% CI = 1.11–2.25, P = 0.012 for CHIP−/AgeAccelHG+.

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