Distinct mutational features across preinvasive and invasive subtypes identified through comprehensive profiling of surgically resected lung adenocarcinoma.

Based on our findings, EGFR and TP53 mutations were detected from most tumors having an increasing trend concomitant with increased invasiveness, resulting in more predominant mutations in IAC ( EGFR : 30.1% vs. 56.4% vs. 71.5%; TP53 : 0.8% vs. 4.2% vs. 36.2%).

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