In a prospective cohort study, the authors showed a highly significant reduction in Demodex mites within the first week of topical ivermectin treatment, but also a significant down-regulation of the pro-inflammatory genes interleukin-8 (IL-8), cathelicidin peptide LL-37, beta-defensin-3 (HBD3), TLR-4 and tumour necrosis factor-alpha (TNF-α), concomitantly with significant clinical improvement of both signs and symptoms of rosacea ( 24 ).
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The Importance of Assessing Burning and Stinging when Managing Rosacea: A Review.
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