Characterisation of the Circulating Transcriptomic Landscape in Inflammatory Bowel Disease Provides Evidence for Dysregulation of Multiple Transcription Factors Including NFE2, SPI1, CEBPB, and IRF2.

J Crohns Colitis · 2022 · PMC9426667 · PMID 35212366

Europe PMC DOI

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highly significantp = 4.05 × 10 -118actually significant

Results Disease-specific transcriptomes were defined in IBD [8697 transcripts], CD [7152], and UC [8521], with the most highly significant changes in single genes, including CD177 (log 2 -fold change [LFC] = 4.63, p = 4.05 × 10 -118 ), MCEMP1 [LFC = 2.45, p = 7.37 × 10 -109 ], and S100A12 [LFC = 2.31, p = 2.15 × 10 -93 ].

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