These negative correlations were not a generic consequence of clade 2 being on the chromosome and clades 3 and 4 on plasmids, since the correlation of clade 1 (also on the chromosome) and clade 3 was positive (marginally statistically significant, P = 0.05).
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Comparative Analysis of Diverse Acetyltransferase-Type Toxin-Antitoxin Loci in Klebsiella pneumoniae.
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Though somewhat less pronounced, the same pattern was also observed for clades 2 and 4, where we also found statistically highly significant deviations from the Poisson distributions ( Fig. 7B and D ).