highly significantP = 2.6 × 10 −266
Similarly, for sites detected in standard alignment and PAC (but not WASP-filtered data), PAC quantification is highly significant (496 sites, R 2 = 0.956, P = 2.6 × 10 −266 ) ( Fig. 2 A), showing that PAC performs well at sites with lower coverage that may be missed by other approaches.