Exploring the Value of Additional Primary Tumour Excision Combined with Systemic Therapy Administered in Different Sequences for Patients with de Novo Metastatic Breast Cancer.

Breast J · 2022 · PMC9436631 · PMID 36082023

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.0900

boldest claim

The sentences

approached the borderline of significanceP =0.07so close (0.05 < p ≤ 0.1)

In terms of the effect of distant site surgery on patients with single-organ metastasis, multivariate analysis in patients with lung-only metastasis showed that receipt of distant site surgery approached the borderline of significance in reducing the risk of BCSD (SHR: 0.61; 95% CI: 0.36–1.03; and P =0.07) and reached the level of significance in reducing the risk of all-cause death (HR: 0.47; 95% CI: 0.29–0.75; and P =0.002).

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a numerical trendP =0.09so close (0.05 < p ≤ 0.1)

In the subgroup of patients younger than 40 years old, a numerical trend was observed in favour of systemic therapy after primary surgery compared with systemic therapy alone in terms of BCSS (SHR: 0.81; 95% CI: 0.64–1.03; and P =0.09).

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