Transcriptome Analysis of Peripheral Blood Mononuclear Cells Response in Patients with Severe COVID-19 Reveals Crucial Genes Regulating Protein Ubiquitination.

Med Sci Monit · 2022 · PMC9438463 · PMID 36031751

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Then, using biological process enrichment analysis, we found that 6 genes ( ITCH , TRIM21 , RNF130 , FBXO11 , UBE2J1 , and ASB16 ) from this cluster were highly significant in the protein ubiquitination process, which showed that ubiquitination played a major role in the biological processes at the mRNA level during severe COVID-19 in the present study.

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