Ovarian Function Suppression: A Deeper Consideration of the Role in Early Breast Cancer and its Potential Impact on Patient Outcomes: A Consensus Statement from an International Expert Panel.

We believe clinical trials such as those considered herein should not be interpreted in a vacuum and are best understood in the context of the data and observations which came before them; indeed, a possible OFS effect was considered in the earliest adjuvant CT trial ever conducted in breast cancer patients which showed a highly significant impact on disease-free interval for premenopausal patients. 40 This is an especially important consideration for premenopausal patients seeking to retain fertility, as CT-induced OFS is more likely to be permanent.

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