Truth in DAIR: Duration of Therapy and the Use of Quinolone/Rifampin-Based Regimens After Debridement and Implant Retention for Periprosthetic Joint Infections.

Open Forum Infect Dis · 2022 · PMC9439576 · PMID 36072695

Europe PMC DOI

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closest p

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trending toward significanceno p-value reported

Specifically, for knee PJI, there was a significant benefit from a longer duration of rifampin ( P = .025), with the specific comparison of 6- versus 3-month duration trending toward significance (HR, 0.58; 95% CI, .28–1.20).

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may be significantno p-value reported

Therefore, due to possible nonlinearity in the duration effect, the overall test of association may be significant even when the 95% confidence interval (CI) for the HR includes 1.0.

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