The Application of Artificial Intelligence in the Analysis of Biomarkers for Diagnosis and Management of Uveitis and Uveal Melanoma: A Systematic Review.

21 Additionally, principal component analysis was conducted by Ehlers et al to analyze microarray expression results to determine that Nbs1 is a highly significant prognostic factor that can stand alone. 20 There was one study that used bioinformatics to conduct pathway analysis for disease prognosis. 21 CTLA-4 was assessed in 33 types of cancers to determine its expression and pathway via KEGG and GO databases by Zhang et al. 22 Quality of Evidence Most of the studies included in this review were of high quality (94%) and 1 was of moderate quality (6%), as highlighted in Figure 2 .

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