Taz protects hematopoietic stem cells from an aging-dependent decrease in PU.1 activity.

Nat Commun · 2022 · PMC9440927 · PMID 36057685

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Consistent with the previously described role of PU.1 in maintaining HSC quiescence, genes induced after PU.1 depletion in HSC-like cells showed highly significant enrichment for E2F-dependent target genes (Supplementary Fig. 9f, g ).

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