Cytochrome P450-mediated antiseizure medication interactions influence apoptosis, modulate the brain BAX/Bcl-X<sub>L</sub> ratio and aggravate mitochondrial stressors in human pharmacoresistant epilepsy.

Front Pharmacol · 2022 · PMC9441576 · PMID 36515436

Europe PMC DOI

hedged sentences

0.0800

closest p · 1.6× alpha

0.5900

boldest claim

The sentences

an elevated trendp = 0.08so close (0.05 < p ≤ 0.1)

However, phosphorylated ERK (Thr980) levels showed an elevated trend in the CYP substrate + CYP inducer group compared to the NON-CYP + CYP substrate group ( p = 0.08).

also in 278 other papers

an increasing trendp = 0.59not close (p > 0.1)

Compared to the NON-CYP + CYP substrate and NON-CYP + CYP inducer groups, epileptic brain tissues from the CYP substrate + CYP inducer group showed an increasing trend in levels of BAD ( p = 0.59 and 0.085, respectively), although not significant ( Figure 1B ).

also in 63,971 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.