Cyclic di-AMP as endogenous adjuvant enhanced BCG-induced trained immunity and protection against <i>Mycobacterium tuberculosis</i> in mice.

Front Immunol · 2022 · PMC9445367 · PMID 36081510

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an increasing trendno p-value reported

rBCG-DisA immunized mice showed an increasing trend on the transcription levels of IFN-γ, IL-2 and IL-10 in the spleen after M. tuberculosis infection, though no significant differences compared with that of UN and BCG immunized mice ( Figure 2A ).

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