Role of 3'-Deoxy-3'-[<sup>18</sup>F] Fluorothymidine Positron Emission Tomography-Computed Tomography as a Predictive Biomarker in Argininosuccinate Synthetase 1-Deficient Thoracic Cancers Treated With Pegargiminase.

Only PET4 revealed an SUVmax change significantly different from baseline ( p = 0.002) Cohen’s kappa test revealed some agreement of k equals to 0.38, with a marginal significance ( p = 0.043) between PET2 and CT4 across all groups.

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Although we have found evidence to support FLT-PET imaging in the evaluation of the arginine-ASS1-ADI pathway in thoracic cancers (especially MPM), the small sample size, high dropout, wide confidence intervals, and barely significant p values suggest that further evaluation is warranted.

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