Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD.

Mol Neurodegener · 2022 · PMC9447339 · PMID 36064424

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0.0510

closest p · 1.0× alpha

0.0510

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marginally significantp = 0.051so close (0.05 < p ≤ 0.1)

Here the main effect of ɑ-syn pff was more pronounced ( F (1,84) = 7.55, p = 0.0070), and there was a marginally significant ɑ-syn pff x age x sex interaction (F1,84 = 3.91, p = 0.051). ɑ-syn pff significantly reduced this ratio at 3 months post-injection in aged females ( p < 0.05) and in all aged mice combined ( p < 0.01) (Fig. 2 D).

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