Designing multi-epitope-based vaccine targeting surface immunogenic protein of Streptococcus agalactiae using immunoinformatics to control mastitis in dairy cattle.

BMC Vet Res · 2022 · PMC9449294 · PMID 36071517

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extremely significantno p-value reported

In this study, numerous immunoinformatics methods were employed to design a multi-epitope vaccine against mastitis using different T-cell (CTL and HTL) and B-cell epitopes and the extremely significant protein, Sip, which is defined as immunogenic.

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an increasing trendno p-value reported

The results revealed that the initial deviation had an increasing trend in all three systems (i.e., multi-epitope vaccine model, vaccine-TLR2, and vaccine-TLR4) until 40–50 ns.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.