Use and safety of aprotinin in routine clinical practice: A European postauthorisation safety study conducted in patients undergoing cardiac surgery.

4 , 6 The first showed a highly significant detrimental effect of aprotinin on renal injury and failure, 4 and according to the second, there was a significant difference in the proportional rise in plasma creatinine between patients treated with aprotinin and those given epsilon-aminocaproic acid or no treatment. 6 Nevertheless, using the same data from the first study, 4 aprotinin was not mentioned as a risk factor for renal injury. 31 Moreover, in the study, which led to the precautionary suspension of aprotinin (BART study), 7 no difference in renal injury or failure occurrence was observed between aprotinin and lysine analogues.

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