Intrinsic brain activity reorganization contributes to long-term compensation of higher-order hearing abilities in single-sided deafness.

Although the SSD patients with deafness durations <3 years had lower average PTA both for deaf ears ( t = −3.25, p = 0.002) and for normal ears ( t = −2.03, p = 0.048) than SSD patients with longer deafness durations, SSD patients with longer deafness durations showed a significant reduction in RMS error ( t = −2.49, p = 0.018), a marginally significant reduction in the SIN threshold ( t = −1.95, p = 0.060), and a marginally significant increase in ASL ( t = 1.97, p = 0.057) than SSD patients with deafness durations of <3 years (see Figure 1A ).

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Moreover, we observed a decreasing trend of ALFF in several regions in patients with SSD compared with those with NHs.

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