Novel AR/AR-V7 and Mnk1/2 Degrader, VNPP433-3β: Molecular Mechanisms of Action and Efficacy in AR-Overexpressing Castration Resistant Prostate Cancer In Vitro and In Vivo Models.

Interestingly, the effect of VNPP433-3β at 20 mg/kg body weight was found to be highly significant as indicated by the smallest tumor size among the treated groups with a calculated tumor growth inhibition (TGI) of 86% whereas galeterone (100 mg/kg) and VNPP433-3β at 10 mg/kg were comparable with a TGI of 74 and 79%, respectively.

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