Defining the Immune Checkpoint Landscape in Human Colorectal Cancer Highlights the Relevance of the TIGIT/CD155 Axis for Optimizing Immunotherapy.

A p -value < 0.05 was considered statistically significant (*), and p < 0.01 (**), p < 0.001 (***) and p < 0.0001 (****) as highly significant. 3.

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However, there was a statistical trend toward higher frequency and MFI in CD3 + TILs expressing ICs in CMS1 (containing mainly MSI tumors) versus the other subgroups (significant for Tim-3 (Dunn’s multiple comparisons test, p = 0.0382) and TIGIT (Kruskal–Wallis test, p = 0.0446)) ( Figure S3A,B ).

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We observed an overall trend towards an increase in all five ICs in stage II CRC and a decrease in stage III, although these trends were not statistically significant (except for Tim-3 in terms of frequency, p = 0.011), probably due to the high inter-patient variability within the pTNM stages.

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